Product Name: Terlipressin Acetate; Appearance: White to off-white solid powder; Hygroscopicity: Hygroscopic. Weight increment should be not less than 15%; Solubility: Freely soluble in water, 1% acetic acid aolution; pH: 5.0 to 7.0; Water Content: No more than 5.0%; Acetic acid content: No more than 10.0%; Bacterial Endotoxins: no more than 2.5EU/mg; Assay: 95% to 105%, caculated with reference to the anhydrous, acetic acid-free substance
Terlipressin Acetate is an analogue of vasopressin used as a vasoactive drug in the management of low blood pressure. It has been found to be effective when norepinephrine does not help.Indications for use include norepinephrine-resistant septic shock and hepatorenal syndrome. In addition, it is used to treat bleeding esophageal varices.
Terlipressin is a medicine similar to a naturally occurring present in the body, known as antidiuretic (ADH) or vasopressin. ADH has two main effects in the body. Firstly, it causes narrowing of blood vessels (vasoconstriction), thereby limiting blood flow to a particular area of the body. It also acts on receptors in the kidney to retain water in the body, which helps to prevent excessive loss of water in the urine.